Myelodysplastic syndromes. A multiparametric study of prognostic factors in 336 patients
نویسندگان
چکیده
منابع مشابه
Prognostic factors in myelodysplastic syndromes.
UNLABELLED BACKGROUND Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cell and are characterized by ineffective hematopoiesis with normo- or hyper cellular bone marrow and cytopenia(s).The natural evolution of the disease consists of bone marrow failure (leading to infectious and hemorrhagic episodes or anemia related complications) and transformation to acute myel...
متن کاملInfluence of Prognostic Factors on OverallSurvival in Myelodysplastic Syndromes
BACKGROUND Accurate prediction of a patient's prognosis is useful to define the risk posed by the disease. Age, gender, peripheral blood cytopenia, proportion of bone marrow (BM) blasts, performance status, comorbidities, transfusion dependence, specific karyotype abnormalities and molecular biomarkers can refine the prediction of prognosis in MDS. AIM to assess the influence of the some prog...
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The myelodysplastic syndromes (MDS) provide a clinical model for evaluating the evolution of a relatively indolent malignancy into one which is frankly aggressive. The morbidity and mortality in this myeloid clonal hemopathy relate to either marrow dysfunction associated with ineffective hematopoiesis and its peripheral blood cytopenias or to disease evolution into a variant of acute myeloid le...
متن کاملHematopoietic growth factors in myelodysplastic syndromes.
Hematopoietic growth factors (HGFs) continue to be the most widely prescribed class of medications for patients with myelodysplastic syndromes (MDS), despite the advent of disease-modifying therapies for MDS (eg, azacitidine, decitabine, and lenalidomide) and the current absence of an MDS-specific US Food and Drug Administration (FDA)-approved indication for any of the HGFs. Erythropoiesis-stim...
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ژورنال
عنوان ژورنال: Cancer
سال: 1987
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19871215)60:12<3029::aid-cncr2820601229>3.0.co;2-4